Wolowitz: Why do you have all of these unopened paychecks in your desk?
Sheldon: Because most of the things I'm planning to buy haven't been invented yet.

Wolowitz: Damn paper cut. Nothing worse than a paper cut!
Raj: Obviously you don't remember your circumcision.

I'd take Sheldon to Switzerland, absolutely. And I'd leave him there.

Wolowitz [about Sheldon]: How long's he been stuck?
Leonard: Intellectually about 30 hours, emotionally about 29 years.
Wolowitz: Have you tried rebooting him?
Leonard: No, I think it's a firmware problem.

I don't like to kiss and tell, but somebody made it to eighth base!

Wolowitz: I once dated a girl who believed she was abducted by aliens.
Leonard: And that didn't bother you?
Wolowitz: Au contraire; it meant she was gullible and open to a little probing.

Raj: Good news guys, I got the four hour special edition of Watchmen.
Leonard: Got it.
Wolowitz: Seen it.
Sheldon: Detailed analysis posted online.

It's not enough you get the prom queen, you have to get the head of the decorating committee, too?

Wolowitz: In romance, like show business, always leave them wanting more.
Leonard: What does that mean?
Penny: He struck out.

Katee: Thanks, Howard. Always nice to be part of your masturbatory fantasies.
Wolowitz: Come on, Katee. Don't make it sound so cheap.
Katee: I'm sorry. Fiddling with yourself in the bathtub is a real class act.

Wolowitz [about Bernadette]: She wants a commitment, but I'm not sure if she's my type.
Penny: She agreed to go out with you for free. What more do you need?

Wolowitz: Before you and Penny hooked up, did she ask for any sort of commitment?
Leonard: No, she was pretty clear about wanting to keep her options open.

TBBT Quotes

Mrs. Cooper: Shelly! I'm so glad you're here!
Sheldon: I saw you having naked sex.

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.