Wolowitz: Okay! Let me just go inside and slip off my underwear.
Leonard: Why?
Wolowitz: Well if I get lucky, I certainly don't want to be caught in my Aquaman briefs.

Raj: The Wolowitz coefficient?
Wolowitz: Neediness times dress size squared

Wolowitz: According to Alicia's Facebook page, she's hooking up with one of the producers on CSI.
Penny: Dead whore on TV, live one in real life.

Wolowitz [to Penny in sweats]: Penny, Let me take this opportunity to point out that you are looking particularly ravishing today.
Penny: Not with a thousand condoms, Howard.
Wolowitz: So there is a number?

Raj [referring to making Penny Blossoms]: You know if I wanted to do this on a Saturday night, I would have stayed in India
Wolowitz: Drop the third world country act. Your father was a gynecologist and you had a houseful of servants
Raj: We only had four servants and two of them were children

Penny: It looks like the MySpace page of a 13 year old girl
Leonard: No it doesn't
Wolowitz: Oh please, Dateline could use it to attract predators

Howard: you know what would bea great idea? We get some girls over here and we play laser obstacle strip chess
Leonard: Believe me howard, any girl who would want to play that, you don't want to see naked
Howard: You underestimate me

Hi, I'm the small package good things come in

Wolowitz [to Sumemr Glau]

Normally, around women he has the personality of a boiled potato. Put one beer in him, and he has the personality of M. Knight Charmalarmalon

Wolowitz [about Raj]

Wolowitz: Unlike you, I can actually talk to women while I'm sober.
Raj: You fail to take into account that even mute, I am foreign and exotic, while you on the other hand, are frail and pasty.
Wolowitz: Well ... you know the old saying: "Pasty and frail, never fail"

I have eleven hours with her in a confined space. Unless she's willing to jump off a moving train and tuck and roll down the side of a hill, she will eventually succumb to the acquired taste that is Howard Wolowitz

Wolowitz [about Summer Glau]

Wolowitz: Ma, you gotta rent me a tux!
Mrs. Wolowitz: Right now? What kind of sex are you having up there?

TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.