Howard: They spent a ton of money developing this dandruff medication that had the horrible side effect of anal leakage.
Raj: Is there a good anal leakage?

Raj: Aren't you gonna to eat lunch?
Howard: Nah, I blew my food allowance on Pokemon cards?

Bernadette: No, here's how love works. You're gonna return the machine or you can print out a working set of lady parts and sleep with those.
Howard: [pondering]
Bernadette: Oh, my God! Are you actually thinking about it?

Raj: Oh, okay, great. Now, I can look like Val Kilmer as Batman, instead of Val Kilmer as he looks today.
Howard: All right, you can suck it in a little bit.

Leonard: Maybe it's a shipping problem.
Howard: What?
Leonard: Maybe Wesley Snipes and Toucan Sam just got action figures that look like you guys.

My wife came with both fun bags and money bags.

Well, I wanted everyone to know that I love me wife and nobody to know I forgot to turn off the laser.

Raj: Are they actually arguing about comic books?
Leonard: No, that can't be right.
Howard: Maybe "Thor's Hammer" is a new color of nail polish.

Cop: You guys need me to call someone? I'm guessing your moms?
Leonard: Thanks, but we've got it covered.
Howard (walks up): Okay, I just talked to my mom.

Look, Leonard. There's a bridge. Drive off it.

Raj: I talk with my eyes.
Howard: You look like my little cousin when he's dropping one in his diaper.

Stuart: What's wrong with Christmas?
Sheldon: Where to begin? Trees indoors, overuse of the words "tis" and "twas," and the absurd custom of one stocking. Everyone notice socks belong in pairs. Who uses one sock?
Howard: A pirate with a peg leg.
Sheldon: Actually, that helps. Thank you.

TBBT Quotes

Penny: Hey, Sheldon, did you change your Wi-Fi password again?
Sheldon: Yes, it's "Penny, get your own Wi-Fi." No spaces.

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.