Raj: I didn't know you can have a cyst inside a cyst.
Mrs. Wolowitz: The doctor said they were like Russian nesting dolls.

Howard: They spent a ton of money developing this dandruff medication that had the horrible side effect of anal leakage.
Raj: Is there a good anal leakage?

Raj: Aren't you gonna to eat lunch?
Howard: Nah, I blew my food allowance on Pokemon cards?

Bernadette: No, here's how love works. You're gonna return the machine or you can print out a working set of lady parts and sleep with those.
Howard: [pondering]
Bernadette: Oh, my God! Are you actually thinking about it?

Raj: Oh, okay, great. Now, I can look like Val Kilmer as Batman, instead of Val Kilmer as he looks today.
Howard: All right, you can suck it in a little bit.

Leonard: Maybe it's a shipping problem.
Howard: What?
Leonard: Maybe Wesley Snipes and Toucan Sam just got action figures that look like you guys.

My wife came with both fun bags and money bags.

Well, I wanted everyone to know that I love me wife and nobody to know I forgot to turn off the laser.

Raj: Are they actually arguing about comic books?
Leonard: No, that can't be right.
Howard: Maybe "Thor's Hammer" is a new color of nail polish.

Cop: You guys need me to call someone? I'm guessing your moms?
Leonard: Thanks, but we've got it covered.
Howard (walks up): Okay, I just talked to my mom.

Look, Leonard. There's a bridge. Drive off it.

Raj: I talk with my eyes.
Howard: You look like my little cousin when he's dropping one in his diaper.

TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Hey, Sheldon, did you change your Wi-Fi password again?
Sheldon: Yes, it's "Penny, get your own Wi-Fi." No spaces.