MEREDITH: [to Derek] "I am a sink with an open drain, and anything you say runs straight out." [storms off]
GEORGE: "She probably could have used a better metaphor."
IZZIE: "Give her a break, she's got a hangover."

"Oh my God... George is her McDreamy!"

CRISTINA: "Which surgeon are we going to have to suck up to today?"
MIRANDA: "That would be me."
IZZIE: "Dr. Bailey?"

ADDISON: "So, have you made a decision yet, Dr. Stevens?"
IZZIE: [pauses] "What decision..."
ADDISON: "Whether or not you're going to hate me. You're Meredith's friend, and I'm the wicked witch who came in and ruined her life and cheated on Doctor... what is it that you guys call him?"
IZZIE: [gulps] "McDreamy."
ADDISON: "Wow, he must find that embarrassing."
IZZIE: [pauses] "Yeah I think he does."
ADDISON: "Well, you show great potential in my specialty, and since I'm going to be sticking around for awhile, I have a lot to teach if you want to learn. So when you decide how important it is for you to hate me... let me know."

BAILEY: "Izzie, both Dr. Shepherds need an intern up on ICU."
IZZIE: "Wait... both of them, together? Me, by myself, with the two married people who hate each other?"
BAILEY: "Go. Cristina, you're on the thoracotomy."
CRISTINA: "With Burke? I can't have the hateful married couple instead?"

DENNY: "That guy Alex. You with him?"
IZZIE: "No."
DENNY: [smiles] "Good. That means I won't have to fight him for you."
IZZIE: "What makes you think I want you to fight him for me?"
DENNY: "You're in love with me. I'm well off, but not into money. I'm smart, but not a know-it-all. I'm funny, I love animals. And I'm hot. I'm a catch, if you can wrap yourself around the enlarged failing heart."
IZZIE: "You're right. I am sooo in love with you. It's a shame, really, since I'm with Hildy and all."

IZZIE: "How can someone be so offensive, yet so charming all at the same time?"
ALEX: "It's an art form."

[rips off her shirt, throws it at Alex] "Fine! Let's look at that tattoo up close and personal, shall we? What are these? Oh, my God! Breasts! How does anybody practice medicine hauling these things around? And what have we got back here? Let’s see if I remember my anatomy. Glutes, right? Let’s study them, shall we? Gather around and check out the booty that put Izzie Stevens through med school! Have you had enough, or should I continue, because I have a few more very interesting tattoos. You want to call me Dr. Model? That's fine. Just remember that while you're still sitting on two hundred grand of student loans... I'm out of debt."

PATIENT: "You know the dream where you wake up in high school and you’re naked?"
IZZIE: "Yeah."
PATIENT: "Well I would really, really like to wake up. "

GEORGE: "Who else did you invite?"
CRISTINA: "Izzie, we said the list was jocks only. Surgery, Trauma, Plastics. Who else?"
IZZIE: "Just some people from Peds."
CRISTINA: "You invited the preschoolers to Meredith’s house. The next thing you’ll say is you invited the shrinks."
IZZIE: [looks away]
CRISTINA [Izzie looks away]: "She invited mental defects. This party’s DOA."

IZZIE: [comes home, sees Meredith drunk] "Holy Mother of Destruction."
MEREDITH: "You missed Doctor Palooza."
IZZIE: "Apparently you didn't."
MEREDITH: "I should probably never speak to you again."

GEORGE: "Why are you trying to make this about you?"
IZZIE: "It's not about me! It's about me wanting to talk to you about you needing so much sex your girlfriend's vagina's broken."

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey