Penny: What actor holds the record for being named People magazine's Sexiest Man Alive?
Sheldon: William Shatner!
Leonard: I don't think it's Shatner.
Sheldon: Then it's got to be Patrick Stewart

Leonard: Hi. I'm Leonard. You are beautiful. You pop, sparkle and buzz electric. I'm going to pick you up at eight, show you a night you will never forget.
Raj: Where are we going?

Leonard: Alright, get some rest and drink plenty of fluids.
Sheldon: What else would I drink? Solids? Gases? Ionized plasma?
Leonard: Drink whatever you want

Raj: Woh, woh, woh! I don't want to speak to the FBI.
Leonard: Why not?
Raj: I'm brown and I talk funny.

When I die, you can rent a bounce house.

Leonard: You think we can outrun him?
Sheldon: I don't need to outrun him. I just need to outrun you.

Your element does not exist!

Mrs. Hofstadter [about Penny]: If you want to have sex with that woman, find out what kind of cologne her father wore
Leonard: Hello mother

Leonard: Can we talk?
Penny: We can, but the part of "Penny" might get cut.

Look, Howard, I'd say there's lots of fish in the sea, but I've seen you dangle your hook in that water for years, do not throw her back.

Penny: Hey, how come you've never done anything romantic to celebrate our first date?
Leonard: Well, for starters, you've broken up with me so many times, which first date are we talking about?

If they took all the money trying to make a decent Hulk movie, they could probably just make an actual Hulk.

TBBT Quotes

I just gave you my virginity, woman. Cool your jets!

Sheldon

(Singing) Thor and Dr Jones, Thor and Dr. Jones. One plays with lightening, the other plays with bones.

Howard and Raj