[narrating] "After careful consideration and many sleepless nights, here’s what I've decided. There's no such thing as a grown-up. We move out, we move away from our families. But the basic insecurities, the fears and all the old wounds just grow up with us. Just when you think life has forced you to truly become an adult, your mother says something like that. We get bigger, taller, older. But, for the most part, we're still a bunch of kids, running around the playground, trying desperately to fit in."

MARK: "You and I are the dirty mistresses."
MEREDITH: "I suppose we are. Why do you think that is?"
MARK: "My $400-dollar-an-hour shrink says it’s because behind this rugged and confident exterior, I'm self-loathing and self-destructive to an almost pathological degree."
MEREDITH: "We have a lot in common."
MARK: "It's funny. Derek walks in on me naked with his wife, and just turns around and walks away. But then he sees me so much as talking to you, and I'm on the ground bleeding. Interesting, don't you think?"

GEORGE: "Why is he suturing his own face?"
CRISTINA: "To turn me on..."
ALEX: "Because he's Mark Sloan. The guy is like the go-to plastic surgeon on the east coast."
GEORGE: "That’s the guy Addison was sleeping with."
IZZIE: "Can you really blame her?"
CRISTINA: "No, not really."
GEORGE: "Yes, you can."
MEREDITH: "Well McSexy wants an X-ray to check for fractures and I think it’s a bad idea if I go with him."
GEORGE: "Why?"
ALEX: "I'm on it."
GEORGE: "Why is that a bad idea?"
CRISTINA: "McSexy?"
MEREDITH: "That's not right."
IZZIE: "McYummy?"
CRISTINA: "Mmm... no."
MEREDITH: "McSteamy."
CRISTINA: "There it is!"
IZZIE: "Yup."
GEORGE: "Allow me to choke back some McVomit."

PATIENT: "I was struck by lightning."
MEREDITH: "You mean you fell out of a tree that was hit by lightning."
PATIENT: "Same difference."
MIRANDA: "Actually, medically, it's not the same difference. And it would be helpful if, from now on, you told us the whole truth!"

[narrating] "Superstition lies in the space between what we can control and what we can't. Find a penny, pick it up, all day long you'll have good luck. No one wants to pass up a chance for good luck. But does saying it 33 times really help? Is anyone actually listening? Why do we bother doing those strange things? We rely on superstitions because we're smart enough to know we don't have all the answers.. and that life works in mysterious ways. Don't diss the juju, from wherever it comes."

[narrating] "My college campus has a magic statue. It’s a tradition for students to rub its nose for good luck. My freshman roommate really believed in it and insisted on rubbing its nose before every exam. Studying might have been a better idea. She flunked out her sophomore year. But we all have little superstitious things that we do. If it's not believing in magic statues, it's avoiding sidewalk cracks or always putting our left shoe on first. Knock on wood. Step on a crack, break your mother's back. The last thing we want to do is offend the gods."

MEREDITH: "George is still ignoring me."
CRISTINA: "Just ignore him back."
MEREDITH: "Derek says I should apologize until he listens."
CRISTINA: "Derek says?"
MEREDITH: "It's good advice. He's my friend. That’s good friend advice."

ALEX: "O'Malley, you are a pathetic excuse for a man."
GEORGE: "Excuse me?"
ALEX: "You heard me. You're like a whiny little girl.
MEREDITH: "Alex!"
ALEX: [to Meredith] "You know why he's not speaking to you, because he's not over you."
ALEX: [to George] So you got laid and it went badly. A man would move on. But you? You mope around like a dog that likes to get kicked. You make me sick. If it wouldn’t get me thrown out of the program, I'd smash your pathetic little face right into that locker."

DEREK: "Seattle has ferryboats?"
MEREDITH: "Yes."
DEREK: "I didn’t know that. I've been living here six weeks, and had no idea there were ferryboats."
MEREDITH: "Seattle is surrounded by water on three sides."
DEREK: "Hence the ferryboats. Now I have to like it here. I wasn’t planning on liking it here, since I'm from New York, and am genetically engineered to dislike everywhere except Manhattan. But I do have a thing for ferryboats."
MEREDITH: "I'm not going out with you."
DEREK: "Did I ask if you'll go with me? Do you want to go out with me?"
MEREDITH: "I'm not dating you and I'm definitely not sleeping with you again. You're my boss."
DEREK: "No, I'm your boss' boss."
MEREDITH: "You're my teacher and my teacher's teacher. And my teacher!"
DEREK: "I'm your sister. I'm your daughter."
MEREDITH: "You're sexually harassing me."
DEREK: "I'm just riding in an elevator."
MEREDITH: "Look, I'm drawing a line. The line is drawn. Thereis now a big line."
DEREK: "So this line... is it imaginary or do I need to get you a marker?"

[narrating] "The game. They say a person either has what it takes to play, or they don’t."

CRISTINA: "You know, [Burke] is acting like I committed a crime. Like my apartment is full of stolen goods. He’s acting like I kept my apartment to hide stolen goods, so I could do illegal organ transplants for money."
MEREDITH: "Are you sure he’s not just acting like you lied to him about moving in?"
CRISTINA: "What the hell's wrong with you?"
MEREDITH: "My mother's a filthy whore."

MARK: [walks into the bar] "Is this seat taken?"
MEREDITH: [pauses] "I guess not."
MARK: [sits] "You look sad."
MEREDITH: "I just saw my father for the first time in 20 years."
MARK: "How’d that go?
MEREDITH: "It could have gone better. What’re you still doing here?"
MARK: "I'm hoping Addison shows up."
MEREDITH: "You're still in love with her?"
MARK: "You're still in love with Derek."
MEREDITH: [pauses] "She won't show, you know."
MARK: "No?"
MEREDITH: "He’s not the kind of guy you leave if you can help it."
MARK: "But what if you're wrong? Just this once, what if life comes down on the side of the dirty mistresses?"

Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."