Leonard: What am I doing in your spam folder?
Sheldon: I put you there after you forwarded me a picture of a cat playing the piano entitled, "this is funny."

Sheldon: Roommates agree that Friday nights shall be reserved for watching Joss Whedon's brilliant new series, "Firefly."
Leonard: Does that really need to be in the agreement?
Sheldon: Might as well settle it now; it's going to be on for years.

Wheaton: Embrace the Dark Side!
Sheldon: That's not even from your franchise!

Can I get you something? A feminine hygiene product or a bowel-regulating yogurt?

Dr. Plimpton, Penny is a waitress who doesn't understand the role gasoline plays in the internal combustion engine.

Leonard: Well, it wasn't my fault.
Sheldon: The implication being that you somehow tripped and fell into her lady parts?

Dr. Plimpton: What if there's a disaster that destroys all of the USB ports?
Sheldon: Then there's really no reason to live, is there?

Leonard: I think any university would want you -- except, of course, any university that had already had you, because they would have already wanted you, before they, you know, got you.
Sheldon: From the mind that brought you "hi-lo."

I have a lady friend who will be staying with me for a few days. I want her to feel at home; I also bought scented soaps, pantyhose, Midol, calcium chews, and what is apparently a yogurt specifically designed to regulate the female bowel.

Leonard: Are you planning on kidnapping a woman?
Sheldon: Sarcasm?
Leonard: Yes, but mixed with a little bit of concern.

And now, as promised, the tangent. Sheldon and the Hell-hound. Or. How I Lost My Hot Dogs.

Allegiance to male comrades before women who sell their bodies for money.

TBBT Quotes

You can't ruin a friendship with sex that's like trying to ruin ice cream with chocolate sprinkles.

Raj

Sheldon: Even the dung beetle chooses to plot its course by using the Milky Way.
Raj: Is that true?
Sheldon: Everything I say is true. Now, of course, the dung beetle also enjoys eating fece, living in feces and making little balls out of feces. So, pick and choose which aspects of its lifestyle you want to embrace.