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Homer: Doc, this is all too much. I mean, my son a genius? How does it happen?
Dr. Pryor: Well, genius-level intelligence is usually the result of heredity and environment.
(Homer looks confused.)
Dr. Pryor: Although, in some cases, it's a total mystery.

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The Simpsons Quotes, The Simpsons Season 1 Episode 2 Quotes, Homer Simpson Quotes
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The Simpsons Season 1 Episode 2 Quotes

Now go on, boy, and pay attention. Because if you do, one day you may achieve something that we Simpsons have dreamed about for generations. You may outsmart someone.

Homer

(In science lab, Bart is about to mix two substances.)
Ms. Melon: (to Bart) Say, what's that? It looks dangerous.
Bart: Well, it's really pretty top secret, ma'am.
Ms. Melon: All right, keep going. But you do know what happens when you mix acids and bases, right?
Bart: 'Course I do.
(Bart pours one substance into another, it explodes and covers the whole room in the yellow mixture.)
Bart: Sorry.

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