Sheldon doesn't know when he's being mean because the part of his brain that should know is getting a wedgie from the rest of his brain

Bernadette

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Bernadette Quotes, The Big Bang Theory Season 5 Episode 21 Quotes, TBBT Quotes
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The Big Bang Theory Season 5 Episode 21 Quotes

Sheldon: Professor Hawking, it's an honor and a privilege to meet you, sir.
Stephen Hawking: I know.

That's amazing. You'll be like his pit crew.

Leonard