Parker: I don't believe you.
Lynette: Parker I'm your mother! Mothers don't lie to their sons! Now, go wash your hands or Santa's not going to bring you anything for Christmas.

Mike: So how did the two of you meet?
Orson: Oh well I've been her dentist for years... last week i was looking in her mouth and decided to put my tongue in it.

Carlos: My mama worked her fingers to the bone for me!
Gabrielle: That's what put her in an early grave! (long pause) Well that and the hit and run thing...

(stuttering) ...This is pornography for homosexuals!

Eleanor

Karl: Susie, Susie!
Susan: Our marriage was garbage! Stupid, disgusting pile of garbage!
Karl: No, no, don't say that.
Susan: And I regret everything that came of it!
Karl: Don't do this right now.
Susan: Ugh! (to Julie) Except you, honey. You're my rock. (to Karl) Ooh, out! Get out!
Karl: I promise you I'm gonna break up with Edie and make this right. I'll call you when it's done.
Susan: Don't bother! I won't pick up.

Edie's not a slut. She's just popular with indiscriminate men.

Susan

Desperate Housewives Season 2 Episode 19 Quotes

Paul: These little mind games are going to stop, right now!
Felicia: And if they don't, what are going to do? Blow your brains out, like your wife did?

Mrs. Pate: Yesterday afternoon, Parker offered a cookie to Cindy Lou Peeples if she would show him her vagina.
Lynette: What kind of cookie?
Mrs. Pate: What does that matter?
Lynette: Oh, it doesn't. I'm just stalling because I am completely mortified.