Sherlock: Has anyone heard the theory that the CIA created crack cocaine?
Joan: I have
Sherlock: I started that.

Gregson: I've been a cop for 30 years, I carry a gun.
Watson: And a penis.

[To Joan] Oh my God, you had sex with my brother.... Willingly.

Sherlock

[To Sherlock] I am dissecting a body in the middle of the night. We are not having a moment.

Watson

Sherlock: I will never allow any harm to come to you, not ever.
Joan: You can't promise that.
Sherlock: And yet I did.

Sherlock: What are you doing?
Watson: Depriving you of all stimuli; time for you to get some sleep.
Sherlock: What? No, no. Right after you solve a case, you're flushed with a success. We should double down with work.
Watson: We?
Sherlock: You, me, Angus, some combination of the three. You already know I favor you.

In Sherlock Holmes, I believe.

Rhys

Sherlock: She died.
Watson: Irene?
Sherlock: We were quite close, I did not take her passing well.

If you haven't already, I strongly suggest you find yourself a new spatula.

Holmes

Sherlock: Ugh. What is that? I asked for coffee.
Watson: Well, you asked for coffee but you got tea.
Sherlock: No. I'm British. This is not tea.

If something were ever to happen to you, I am not sure I'd be able to forgive myself.

Sherlock

Sherlock: We can tell my father I've hit a bit of a rough patch...
Watson: I took a new job this morning. I'll be starting next week after you and I wrap up.
Sherlock: I see... I'm usually quite good with deductions.
Watson: You okay?
Sherlock: My dear Watson, when ever am I not?

Elementary Quotes

Holmes: Why do you suppose you hate your job so much?
Watson: I don't hate my job.
Holmes: You have two alarm clocks. No one with two alarm clocks loves their job. Two alarm clocks mean it's a chore for you to get up in the morning.

Watson: How do you do it, guess things?
Sherlock: I observe and then I deduce.
Watson: How did you know I was a doctor, you said you could tell from my hands.
Sherlock: Hand, singular. It was soft no calluses.
Watson: How did you know my father had an affair?
Sherlock: Google. Not everything is deducible.