I always imagined you have a secret lair beneath a volcano for such an occasion.

Sherlock [on his father's being in danger]

Yes, let's talk about bees, instead of the execution you just made in Yonkers.

Sherlock

Dr. Hawes: We've talked about this. You don't get to go on the ride until it's your turn.
Sherlock: When it's my turn, I won't really get the full experience.
Dr. Hawes: You want the full experience? Stay there. I'll get my scalpel.

My mother's ghost recently set a room on fire, so I've been doing most of my thinking elsewhere.

Sherlock [to Hawes]

Hawes: Holmes? Anything I can help with?
Sherlock: Not yet. But if an autopsy is in the offing, I should know soon enough.

Joan: [Sherlock] didn't come home last night, and he hasn't returned my calls.
Marcus: Maybe he met someone. Or, knowing him, someone, her two friends and a pet tiger.

Don't pretend you haven't seen her naked. Everyone has seen her naked. But I wouldn't lead with that if I introduce you to her.

Joan [to Marcus]

Imagine the indignity of being told my brain is normal.

Sherlock [to Joan]

My personality hasn't changed.

Sherlock [to Joan]

Drew Bishop: My sister has a lot of ex-boyfriends. Which one is missing?
Sherlock: Sammy Olivetti. Tall. Tattoos. Phallus to make a Clydesdale blush.

Sherlock: You praised me yesterday for talking this all so very well. I'm really not.
Joan: That's OK. I know how scary this is.

If I can no longer function as a detective, I'm not sure I can stay sober. And if I can't stay sober, how's my brain going to heal?

Sherlock