Suicide Booth: Please select mode of death: "Quick And Painless" or "Slow And Horrible".
Fry: Yeah, I'd like to place a collect call.
Suicide Booth: You have selected: "Slow And Horrible".
Bender: Great choice!

Leela: You've been assigned the job you're best at just like everyone else.
Fry: What if I refuse?
Leela: Then you'll be fired...
Fry: Fine!
Leela: ...out of a cannon into the Sun!

Prof. Farnsworth: My god, I am your nephew. This is absolutely incredible!
Bender: Heh-heh, can we have some money?
Prof. Farnsworth: Oh my, no!

Fry: So what do you do, Bender?
Bender: I'm a Bender. I bend girders. That's all I'm programmed to do.
Fry: Were you any good?
Bender: Are you kidding? I could bend a girder to any angle - thirty degrees, thirty-two degrees... thirty-one... but I couldn't go on living once I found out what they were for.
Fry: What?
Bender: Making suicide booths!

Fry: Why would a robot need to drink?
Bender: I don't need to drink. I can quit any time I want!

C'mon, Bender! It's up to you to make your own decisions in life. That's what separates people and robots from animals... and animal robots.

Fry

Bender: You really want a robot for a friend?
Fry: Yeah, ever since I was six.
Bender: Well, okay. But I don't want people thinking we're robo-sexuals, so if anyone asks, you're my debugger.

Fry: Can I ask you a question?
Leela: As long as it's not about my eye.
Fry: Uh...
Leela: Is it about my eye?
Fry: Sort of.
Leela: [sighs] Just ask the question.
Fry: What's with the eye?
Leela: I'm an alien, all right? Now let's change the subject.
Fry: [excited] Cool, an alien. Has your race taken over the Earth?
Leela: No, I just work here.

My God! It's the future. My parents, my co-workers, my girlfriend. I'll never see any of them again. Yahoo!

Fry

Fry: Wait a minute, is that blimp accurate?
Leela: Yep. It's December 31st 2999.
Fry: My God! A million years!

Space; It seems to go on and on forever...but then you get to the end and a gorilla starts throwing barrels at you.

Fry

Fry: Whoa... a real live robot; or is that some kind of cheesy New Year's costume?
Bender: Bite my shiny metal ass.
Fry: It doesn't look so shiny to me.
Bender: Shinier than yours meatbag.

Futurama Season 1 Episode 1 Quotes

(after he freezes Leela)
Fry: See ya' in a thousand years.
(Is about to leave, then comes back and switches it from 1000 years, to five minutes)
Fry: You owe me.

Leela: Look, I know it's not much consolation. But, I understand how you feel.
Fry: No, you don't. I've got no home, no family.
Bender: No friends.
Fry: My whole world is gone. You can't possible understand what it feels like to be so alone.
Leela: I understand. I'm the only one-eyed alien on this whole planet. My parents abandoned me here as a baby and I don't even know what galaxy they were from. I know how it feels to be alone.