Ask most people what they want out of life and the answer is simple - to be happy. Maybe it's this expectation though of wanting to be happy that just keeps us from ever getting there. Maybe the more we try to will ourselves to state's of bliss, the more confused we get - to the point where we don't recognize ourselves. Instead we just keep smiling - trying to be the happy people we wish we were. Until it eventually hits us, it's been there all along. Not in our dreams or our hopes but in the known, the comfortable, the familiar.

Meredith

I gotta go. You stay here. You are a gifted surgeon with an extraordinary mind. Don’t let what he wants eclipse what you need. He’s very dreamy, but he’s not the sun. You are.

Cristina

It's good to be scared. It means you still have something to lose.

Richard

[narrating] "Too often, the thing you want most is the one thing you can't have. Desire leaves us heartbroken, it wears us out. Desire can wreck your life. But as tough as wanting something can be. The people who suffer the most, are those who don't know what they want."

MEREDITH

Izzie: You never know the biggest day of your life is the biggest day. Not until it's happening. You don't recognize the biggest day of your life, not until you're right in the middle of it. The day you commit to something or someone. The day you get your heart broken. The day you meet your soul mate. The day you realize there's not enough time, because you wanna live forever. Those are the biggest days. The perfect days. You know?
Denny: I bet you ... you made a beautiful bride.
Izzie: It was a beautiful day.
Alex: You put the scarf on. I told you, you don't need it. You look gorgeous without it.
Denny: He's right.
Izzie: Go away now. Go away, I wanna be alone with my husband.
Alex: (Takes off her scarf, and kisses her forehead) My wife is hot!
(Izzie giggles and smiles)

Just when we think we figured things out, the universe throws us a curveball. So, we have to improvise. We find happiness in unexpected places. We find ourselves back to the things that matter the most. The universe is funny that way. Sometimes it just has a way of making sure we wind up exactly where we belong.

Meredith

Looking back, it's easy to see when a mistake has been made... to regret a choice that seemed like a decent idea at the time, but if we used our best judgment and listened to our hearts, we are more likely to see that we chose wisely and avoided the deepest most pain regret of them all - the regret from letting something amazing pass you by.

Meredith

Don't wonder why people go crazy. Wonder why they don't. In face of what we can lose in a day, in an instant, wonder what the hell it is that make us hold it together.

Meredith

Nobody chooses to be a freak. Most people don't realize they're a freak until it's way to late to change it. No matter how much of a freak you end up being, chances are there's still someone out there for you. Unless of course, they've already moved on. Because when it comes to love, even freaks can't wait forever.

Meredith

Vulnerability isn't the opposite of strength. It's a necessary part. You have to force yourselves to open up, to expose ourselves, to offer everything we have and just pray that it's good enough. Otherwise, we'll never succeed.

Meredith

[last lines] "I love you too."

George

I'm Michelangelo.

Mark

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith