When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

It's good to be scared. It means you still have something to lose.

Richard

ADDISON: "There is a land called Passive Agressiva, and I am their queen."
DEREK: [smiles] "That's all I'm saying... except when you're shrieking about trout."

Meredith: You can trust me, from here on out.
Maggie: Don't do it again. Don't lie to me again.
Meredith: Okay.
Maggie: Okay.

We’ll try again and we’ll fail again because that’s what progress looks like. Progress looks like a bunch of failures. And you’re going to have feelings about that because it’s sad, but you cannot fall apart. And then one day, we will succeed and save a person’s life and we will walk on the moon.

Meredith

Owen: It's a cute baby, right?
Cristina: Its small features and oversized thighs trigger a hormonal response from humans. It's autonomic. It's what keeps us from eating them.

Derek: I wanna be with you forever, and you wanna be with me forever. In order to do that we need to make vows. A commitment. A contract. Give me a piece of paper.
Meredith: I don't! I... I... I don't. I have post its!
Derek: (takes the post its and a pen) Ok. What do we wanna promise each other?
Meredith: That you'll love me... even when you hate me.
Derek: To love each other, even when we hate each other. (writes it down) No running. Ever! (Mer smiles and comes and sits in front of him) Nobody walks out. No matter what happens.
Meredith: No running.
Derek: (writes it down) What else?
Meredith: That we'll take care of each other, even when we're old, and smelly, and senile. And... if I get Alzheimer's and forget you...
Derek: I will remind you who I am, every day. To take care when old, senile, and smelly (writes it down) This is forever. (signs it) Sign.
Meredith: This is our wedding. A post it? (smiles)
Derek: Mhmmm. If you sign it.
Meredith: (signs it, and hands it back. Has tears in her eyes) Now what?
Derek: Now I kiss the bride. (They kiss)
Meredith: (smiling) Married.
Derek: (smiling) Married. (sticks their post it in Mer's locker) You see that? (Mer nods and smiles) Plenty of time.

[in flashback]
Meredith: I have no story. I'm just a girl in a bar.
Derek: I'm just a guy in a bar.

Don't wonder why people go crazy. Wonder why they don't. In face of what we can lose in a day, in an instant, wonder what the hell it is that make us hold it together.

Meredith

April: Her name is Harriet.
Catherine: Harriet?
April: Um-hmm
Catherine: Oh, I like it. Tubman.
April: Exactly. Tubman, also The Spy, which is a very good book.

Lexie: You have to stop. You gotta stop talking to me and checking on me and talking to my boyfriend. I love you, and I'm always gonna love you, but I don't want to love you. I want to be happy, and Jackson makes me happy. And if you keep pulling at me, I'll come back to you.
Mark: You're right, I'm sorry.
Lexie: You got what you wanted you wanted a family so please just let me have what I wanted.
Mark: I said you're right. I told Avery I was letting you go. Did he tell you that part?
Lexie: Yes, it's paternalistic and weird.
Mark: I'm letting you go, Lexie. That means you've got to walk away.

I don't have to say a word. She just looks at me and sees who I am and how I feel and accepts it. She doesn't try to change it or wants to change it. That person. There's a billion people but I imagine there's only one of her.

Owen

Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)