Why won't you ever let me be happy?

Debbie [to Fiona]

Fiona: You can't have a boy in your bed!
Debbie: Why not? You do!
Fiona: I am a grownup.
Debbie: I'm pregnant!
Fiona: No you're not. No you're not.

Amanda: Does she make you happy or is it just about the sex?
Lip: Sex, mostly.

Bianca: Let's go get drunk and buy a gun.
Frank: A gun?
Bianca: Yeah.

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Fiona: So are you and Kev...
V: Giving it another try.

There's always gonna be people that are going to try and fix us and you can never make those people happy, like it breaks their heart just to look at you.

Monica [to Ian]

We should clarify something, because for me personally, part of feeling alive is being alive!

Frank [to Bianca]

V: You know, having a Russian sex worker isn't ideal for child care.
Kev: Yeah, but she does come in handy.

I know! Lets get crack!

Bianca [to Frank]

I'm not homeless, I told you. I have a home, I'm just not welcome there.

Frank [to Bianca]

Family sucks ass!

Sammi

Bianca: I'm not gonna be alive to pay off my credit card, what does it matter?
Frank: Such wisdom for one so young.

Shameless Quotes

Get your ass up you goddamn ponytail Fabio motherfucker.

Sheila

Sean: You took your monitor off yourself.
Fiona: So?
Sean: So, you should have waited for the P.O. and you know it.
Fiona: That's a technicality. You're gonna judge me for that?
Sean: No, I'm not gonna judge you for that. I find it charming as fuck that you took a screwdriver to your monitor. And I find it sexy as hell that you had a bloody lip before lunch today.
Fiona: Are you making fun of me?
Sean: No. It's just you're a chaos junkie, Fiona. And I'm a junkie, junkie. So I love chaos. And when I get into chaos, bad shit follows.