Stan: Kyle saved your life! The least you could do is thank him!
Cartman: Alright, alright......Kyle......(opens mouth. episode ends)

Dammit! I thought 4th grade was going to be different.

Kyle

Kyle: Look, you guys built a machine together that can bend time. If you just agree with him, you can build another one and usher in a whole new era of science.
Nerd: And live in a world of 72 original Star Trek's? I don't think so. I don't want to live in that world.

Stan: This is it the end of innocence this is the loss of that playful youth that all are parents warned us about
Kyle: I just didn't think it come so soon.
Cartman: Yeah, only now do we realize how we took the 3rd grade for granted.
Kyle: Huh?
Cartman: Everything was great in 3rd grade and now that it's all over we're starting to see how special it was
Cartman: (starts singing) Remember how it used to be? In the 3rd grade we used to laugh and play and cherish each day, in the 3rd grade we learned wondrous things with a teacher so nice sat on marshmallow desks with teddy bear smiles the world all seem to make sense but that sense seemed slowly but, seemed to fade after 3rd grade. In 3rd grade we used to write with crayons we would make sparkly pictures with glitter and glue we had warm cookies and hearts full of love and it wasn't a care in the world for me or for you. There's not in this life that I wouldn't trade just to go back for 1 minute to 3rd grade.
(Clyde starts crying)

Cartman: Suck my balls.
Ms. Choksondik: Present them.
Cartman: What?
Ms. Choksondik: Present: Whip them out and I'll suck 'em.

Kyle: (After Timmy coming back from time) Dude! It looks like Timmy went all over time! He must have alot to tell us!
(pause)
Timmy: Ih, Timmy.

(after Kenny dies) Who didn't see that coming?

Stan

(to Cartman) Shut up, fat ass!

Kyle

Cartman: (jumping up on the desk) Kiss my ass!
(long pause)
Cartman: Oh, you guys are so weak!
Ms. Choksondik: Young man do you have an explanation for this?
Cartman: Oh, I'm sure I do.

I'm gay! I'm gay as a gymnast on shore leave!

Mr. Garrison

After being dismissed from teaching, he went off to write romance novels. His first novel sold very well and everything was fine until he found out his novel won the Gay Pulitzer Prize, and was considered the best homo-erotic novel since 'Huckleberry Finn'.

Mr. Mackey

(Stan, Kyle, and Kenny on seeing Ms. Choksondik.)
Stan: Whoa dude!
Kenny: Her titties are f**king huge!
(later)
Ms. Choksondik: (while writing on the board) My name is Ms. Choksondik.
Stan: More like Ms. Makes-me-sick.

South Park Season 4 Quotes

Kyle: But you know, I've learned something today. You see, the basis of all reasoning is the mind's awareness of itself. What we think, the external objects we perceive, are all like actors that come on and off stage. But our consciousness, the stage itself, is always present to us.
Cartman: Tits.

Cartman: You guys, you guys! Oh my god, seriously, you guys!
Stan: What the hell's wrong with Cartman?
Kyle: He's fat and stupid.