Dean, she was married to Jesus.

Sam

I guess I'm wondering how someone quits one life for something completely different.

Dean

Dean: How long since I've been to confession.
Sam: Never.
Dean: That's too long.

Wanna try that again like you mean it?

Sam

I guess I've seen it all now.

Cole

I couldn't save this one.

Sam

You know you can do everything right, and even still, sometimes the guy still dies.

Dean

Dean, you know what you did back there, it was incredible. If you can do that without losing yourself, that's cause for hope.

Sam

Dean is in trouble.

Sam

Don't worry about Dean. I'll get to him in due time.

Cain

I mean nothing ever really gets deleted from the Internet.

Sam

He just learned how to poke on Facebook.

Sam

Supernatural Quotes

Dean: So you’re saying we’re both a couple of dumbasses.
Cas: I prefer the word trusting. Less dumb, less ass.

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley