I suppose some dumb bastard stood here, felt a jolt of his holy juice and thought 'I'm going to build me a nun factory.' Well, it was the right idea... wrong angel.

Azazel

When you've won, your rewards will be unimaginable. Peace, happiness, two virgins and 70 sluts...

Zachariah

Dean: Tell me something. Where's God in all this?
Zachariah: God? God has left the building.

What's this supposed to be, the suite life of Zach and Cas?

Dean

Dean: I need you to take me to see Sam.
Castiel: Why?
Dean: There's something I have to talk to him about.
Castiel: What's that?
Dean: The BM I took this morning. What's it to you? Make it snappy.

Dean: I'm not sure if he's my brother any more. If he ever was.
Bobby: You stupid stupid son of a bitch! Well boo hoo. I am so sorry your feelings are hurt... princess! Are you under the impression that family's supposed to make you feel good? Make you an apple pie, maybe? They're supposed to make you miserable! That's why they're family.

Dean: Yeah, well, I'll tell you one thing. At this point, I hope he's with Ruby.
Bobby: Why?
Dean: 'Cause killing her is the next big item on my to-do list.
Bobby: I thought you were on call for angel duty.
Dean: I am on call, in my car, on my way to murder the bitch.

If you walk out that door, don't you ever come back.

Dean

You don't know me. You never did, and you never will.

Sam

Dean: Well, it's about time. I've been screaming myself hoarse out here for about two and a half hours now.
Castiel: What do you want?
Dean: Well, you can start with what the hell happened in Illinois?
Castiel: What do you mean?

Dean: How long is this gonna go on?
Bobby: Here, let me look it up in my demon-detox manual. Oh, wait. No one ever wrote one.

Congrats, Sammy. You just bought yourself a benchwarmer seat to the Apocalypse.

Dean

Supernatural Season 4 Quotes

Sam: It's probably a dumbwaiter. All these old houses had them.
Dean: Know-it-all.
Sam: What?
Dean: What?
Sam: You said...
Dean: What?
Sam: Never mind.

Boy, three bedrooms, two baths, and one homicide. This place is going to sell like hotcakes.

Dean