Sheldon: You are the living embodiment of the beautiful Princess Panchali.
Lalita: Oh, no kidding? Who is that?
Sheldon: A beloved character from an Indian folktale.
Lalita: Oh. "Us" Indian or "Come to our casino" Indian?
Sheldon: "You" Indian

Leonard [referring to Sheldon singing]: What got into him?
Penny: Oh, just a couple virgin Cuba Libres that turned out to be kinda slutty

How can I be a gynocologist? I can barely look a woman in the eye!

Raj

I had such plans. I had dreams. I was going to be the Indira Gandhi of particle astrophysics... but with a penis, of course

Raj

Leonard: Look at the bright side. [Lalita] might turn out to be a nice, beautiful girl.
Raj: Great, then we'll get married, I won't be able to talk to her, and we'll spend the rest of our lives in total silence.
Wolowitz: Worked for my parents

Is it just me, or does webchatting with your clothes on seem a little pointless?

Wolowitz

Penny [to Raj about Lalita]: No one can make you get married. Why don't you just meet this girl and see what happens?
Raj: Haven't you been listening to me? I cannot talk to women!
Leonard: Um, Raj?
Wolowitz: No, no, let's see how long it takes him

Sheldon: When I was a little boy and got sick, which was most of the time, my mother would read [The Monkey and the Princess] to me. It's about an Indian princess who befriends a monkey who was mocked by all the other monkeys because he was different. For some reason I related to it quite strongly.
Penny: I know the reason.
Leonard: We all know the reason

Penny: I need some guinea pigs.
Sheldon: Okay, there's a lab animal supply company in Reseda you can try. But if your research is going to have human applications, may I suggest white mice? Their brain chemistry is far closer to ours.
Penny: I swear to God, Sheldon, one day I'm going to get the hang of talking to you.
Leonard: His mom's been saying that for years

Raj [drunk]: Where did my life go, Penny?
[everyone is shocked Raj is talking to Penny]
Raj: One day, I'm a carefree bachelor, and the next, I'm married and driving a minivan to pee-wee cricket matches in suburban New Delhi.
Penny: Are you talking to me?
Raj: Is there another Penny here?

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?

Leonard: Do you really need the Honorary Justice League of America Membership card?
Sheldon: It's been in every wallet I owned since I was five.
Leonard: Why?
Sheldon: It says keep this on your person at all times. It's right here under Batman's signature.

The Big Bang Theory Season 1 Quotes

Leonard: We need to widen our circle.
Sheldon: I have a very wide circle. I have 212 friends on MySpace.
Leonard: Yes, and you've never met one of them.
Sheldon: That's the beauty of it

Leonard: At least I didn't have to invent 26 dimensions just to make the math come out.
Sheldon: I didn't invent them, they are there!
Leonard: In what universe?
Sheldon: In all of them, that's the point