To paraphrase T.S. Elliot, this is how the world ends, not with a bang but with a nephew.

Sheldon

Amy: I'll let you in on a little secret. Originally, we were painted nude. But I had him add clothes cause I thought it was an unnecessary challenge to our heterosexuality.
Penny: Yeah, good call.
Amy: But, if you ever change your mind, all it would take is some warm, soapy water and a couple of sponges.
Penny: You're talking about the painting, right?
Amy: Sure.

I'm trying to raise the temperature in here before my nipples tear through my shirt.

Sheldon

Amy: Goodnight, Painting Penny. Goodnight, Real Penny.
Penny: Goodnight, Real Amy.
Amy: You don't have to say goodnight to Painting Amy, because she's never leaving. Bernadette: Goodnight, Real Penny. Goodnight, Transvestite Penny.

Leonard: It's going to be difficult to find something you are both equally good at.
Raj: Is there anything you are both equally bad at?
Sheldon and Kripke: Sports.

Penny: It's kind of heavy
Bernadette: Too bad you're not as strong as the dude in the painting.

Kripke: Well, as long as we are here I might as well take a leak.
Sheldon: Kripke, you're in my spot

Sheldon: If you're interested I can send you a link to a YouTube video that would show you how to perform your own rectal exam. Helpful hint: trim your nails first.

Now? You realize I'm your boss and I'm holding my penis.

President Siebert

Before I met you, I was a mousey wallflower. But look at me now. I'm like some kind of downtown-hipster-party girl with a posse, a boyfriend and a new lace bra that hooks in the front of all things.

Amy

I'm glad men are wearing hats again. They are so distinguished.

Raj

Howard: Why don't I talk to him about it in May?
Bernadette: In May, you're gonna be on the International Space Station.
Howard: They got a phone.

The Big Bang Theory Season 5 Quotes

You can't blame yourself. When your prefrontal cortex fails to make you happy promiscuity rewards you with the needed flood of dopamine. We, neurobiologists, refer to this as the skank reflex.

Amy

I feel like two totally different people. Dr. Jekyyl and Mrs. Whore.

Penny