You can either be fat and jolly or a skinny bitch. It's up to you.

Cathy

I'm fat and you're gay so we're supposed to get along.

Andrea

Cancer sucks. Put that in your God damned inspirational poster!

Cathy

Cathy: I wanna do it on the grass.
Paul: Really? You want me to do you in the ass?
Cathy: No! GRASS!

Hear that, Marlene? It's time to cross over, you racist bitch!

Andrea

I honestly want to get laid this Thanksgiving. I'm touching my wife under the table right now.

Paul

Dr. Todd [to Cathy]: You have an awesome rack.
Cathy: You say "rack." Really?!?

I'm just gonna have desserts and liquor.

Cathy

You're the yin to my yang, the ping to my pong, the normal to my crazy. Let's be us together.

Paul

I saw my brother's penis. Someone shoot me in the eye.

Cathy

Andrea saw me masturbating... for a big girl, she's stealthy as a fucking puma.

Paul

Cathy: Don't stare yourself. That always backfires.
Andrea: So does binge-eating. But then at least I get to fall asleep with the taste of frosting in my mouth.

The Big C Quotes

Sean: The last you could do is buy a damn Hybrid.
Cathy: The least you could do is take a shower.

Paul: Can we at least figure out what to tell Adam? Because right now, my story is: "Adam, your mom's a meanie!"