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Serena: Wait. If Chuck is really in trouble then we need to help him. He doesn't have any brothers and sisters. We are all he has. You are all he has.
Blair: He doesn't want my help.
Serena: So that's just it? You're going to abandon him for some society matrons?
Blair: Those "matrons" as you call them, are helping me build a life. All Chuck can do is destroy one. I'm not abandoning Chuck. I'm just saving myself.