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Family Guy goes back to its roots with Stewie and his evil genius ways. When Stewie and Brian messes around with Stewie's time-machine, they accidentally remove themselves from the universe and get trapped in a space-time continuum.
During their adventures, they encounter Bertram, Stewie's evil brother, find out that Stewie caused the Big Bang, therefore creating the entire world, and that Leonardo da Vinci is actually Stewie's ancestor.
When Bertram kills da Vinci, Stewie figures out that he is in fact his own "creator" and Brian unearths Stewie from a cryogenic tube underneath the Griffin house.