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- Richard performs his 10,000th surgery, a liver transplant between sisters.
- Derek and Lexie attempt to operate on a kid with an inoperable tumor, which they are not able to do.
- Adele shows up at the hospital, lost in her Alzheimer’s. She believes Richard left her for Ellis and he sings to her during his surgery.
- Mark’s new girlfriend tells him I love you, he doesn’t respond.
- Derek and Mer host a party for Zola. At the party, Cristina and Owen get into a huge argument that everyone overhears.
- Jackson, Alex, and April make plans to move out of the house.