Thanks to a bike race sponsored by the Dead Baby Bar, the ER is teeming with injured riders and pedestrians. One of them is named Viper and after Alex quickl removes the spokes from his abdomen, Meredith is left to finish up. Before Viper is discharged, he kisses Meredith out of nowhere. Sheppard witnesses and claims not to be jealous.

Izzie and Cristina are in charge of an unidentified victim. If there is no sign of brain activity in the next six hours, this man will be declared dead. Izzie makes it her mission to find family of the patient and at least see if organ donation is a possibility. Meanwhile, George is asked to look over a close friend of Dr. Webber who has liver disease.

These two scenarios eventually collide. Cristina isn't exactly sensitive to the wife and daughter of the man once they are found - although Dr. Bailey does prove to have a surprising bedside manner. Nevertheless, the family agrees to donate the dying man's liver to Dr. Webber's friend. Once the organ harvest is complete, Izzie still isn't happy. She wants to sew the man up for the sake of his family and Cristina agrees to help with the cause.