Ellen Sanders is the top surgeon at Maryland College Hospital, recently charged with handling the surgery of the President of the United States. the opportunity has placed a target on her back. She and her family are now the hostages of an apparently rogue FBI agent, Duncan Carlisle, who directed Dr. Sanders to kill the President during his upcoming surgery for reasons unknown.

In this pilot episode, we learn a little about he Sanders family, its dynamics, and the rogue agent holding them hostage. But is Duncan really a pawn in a larger game?