A crane accident leaves many people injured this week, as House, Cuddy and company rush to the scene. House finds one woman, named Hannah, who is trapped beneath the rubble. The fire department wants to amputate her leg to free her, and Cuddy agrees.

But House says they should wait, endearing himself to the patient. Outside the rubble, Cuddy goes off on House for this selfish decision. She had just told him she was engaged to Lucas and thinks he's taking his anger over that out on the case. She really gives it to House, saying he's miserable and wondering why he's fighting so hard for this woman's leg over her life. After all, his leg was saved and look at where it's gotten him: nowhere good.

House fights back and says he's taking life advice from a middle-aged single mother engaged to a man child. But he then goes back down with Cuddy and tells Hannah her leg should come off. He gives a heartfelt speech about his blood clot made him into a bitter person, and she has a family, and she should absolutely not want to be like him. Hannah agrees and House, in a gruesome scene, amputates the leg.

But in the ambulance, with House and her husband by her side, Hannah dies. There was nothing House could have done differently, as it was a side effect of the amputation, but this is far from comforting. Heo goes home and grabs his secret stash of Vicodin. As he's about to down it, Cuddy enters.

She says she called it off with Lucas because she loves House, even if she wishes she did not. House gets up, drops the Vicodin, says he's "the most screwed up person in the world" and they kiss.

In other storyline news, Thirteen drops off a letter in House's office asking for time off. Her Huntington's appears to be causing problems.