It's not even worth dissecting the Case of the Week. A girl lied about meeting a famous comic book creator, which was meant to symbolize the importance of telling the truth.
This led to the episode-concluding admission by Chase: no, he's not having an affair. But, yes, he did kill Dibala. We're left with a stunned Cameron reacting to this news with... silence. How will it affect her relationship with Chase? Spoilers have already given that away.
The crux of the episode involved a medical conference attended by House, Wilson and Cuddy. During it, we see a combination of the new House and the old House.
He actually drugs Wilson in order to prevent him fro giving a speech on euthanasia because it would kill his career. House gives the speech - under someone else's name - instead, thereby getting Wilson's message out there, but ensuring that his friend isn't fired. House also tells Wilson that what he did to a patient recently is okay, it's understandable, it's admirable that Wilson feels guilty about it.
Wilson appreciates the message.
House is also shockingly open with Cuddy. He pretty much admits his feelings to her. But he's then in for a major shock when he discovers Lucas, his former private eye, is on the conference. He's been dating Cuddy for awhile. A more mature House actually acknowledges, though, that Lucas is more stable right now as a boyfriend. Amazing.