Saving Hope doctors react as their Chief of Surgery, Charlie Harris, falls into a coma following a car crash on the way to his wedding to co-worker Alex Reid. His spirit watches over the hospital's happenings as his fiance' and Shahir Hamza (Huse Madhavji) attempt to save his life. Joel Goran, Alex's ex-boyfriend, also works at the hospital and takes over Charlie's patients. In the wake of Charlie's coma, Alex focuses on her patients to keep herself together.

Residents Maggie Lin and Gavin Murphy work together on a case involving accidental poisoning.