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Leonard shows up early to see Penny and keeps it a secret from Sheldon. When his roommate finds out, he's not happy about it at all. Sheldon throws a fit and tells Leonard he doesn't believe anything he's said. Sheldon eventually forgives Leonard.
Howard gets emotional and testy after being absorbing a high level of estrogen when applying the creme to his mother's back. He's gained weight, believes his boobs have gotten bigger, and cries at everything.