Pope Alexander's money is depleted by his expensive rise to power, so he seeks funds through a profitable marriage for Lucrezia that will ally with him Milan.

Prince Djem of Turkey arrives and begins courting Lucrezia. Juan plots an assassination of the prince only to fail upon first attempt. He then finishes the deed by suffocating him.

Cesare sends Micheletto to Naples to rid them of Della Rovere. He fails to assassinate the Cardinal, but escapes the city unscathed.