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When Homer bonds with Flanders' parents and joins them in mocking him, Flanders get so angry that he punches Homer, causing damage to his eye. Flanders feels guilty afterwards and asks Homer to punch him back to settle the score. However, Homer likes being the better man and refuses to do so. Meanwhile, Lisa is having trouble at school because the new substitute (voiced by Tina Fey) hates Lisa and bullies her at school. Going to Skinner and Chalmers doesn't help, so Homer enlists Edna (Flanders' wife) to get rid of the substitute. Edna moves Bart to her class and Ms. Cantwell quits right away. It is only then that Lisa finds out that Ms. Cantwell hated her because she thought she was one of the pretty, popular girls.