After falling off the roof, an injured Alan needs Charlie to help take care of Jake.  Charlie is fine with it until it interferes with his social agenda.

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Two and a Half Men Season 3 Episode 1 Quotes

Charlie: Mixing those pills with alcohol is really a bad idea.
Alan: Not if you're trying to kill yourself

Charlie: Hey, buddy, how you been?
Jake: Life stinks.
Charlie: Cheer up, you're still a kid. It gets much worse