Dempsey joined Grey's in 2005 instantly becoming McDreamy Derek Shepherd. Before that he had a role in The Practice (2004) - also as a doctor - as well as a part in Once and Again (2000-2002) as Aaron Brooks. He was known more for movies than television until Grey's.
In 1987 Dempsey went from dorky to dreamy as the lawnboy who went to great lengths to win the heart of the popular girl next door. I don't know any girl from that time who didn't want to be Amanda Peterson who starred as Cindy Mancini. Sidenote - Seth Green costarred!
Dempsey's first role was in Heaven Help Us (1985) as Corbet. A movie about catholic school boys starring Donald Sutherland, Andrew McCarthy, Mary Stuart Masterson and Kevin Dillon. Not bad for a first credit, right?!
The same year Chambers joined Grey's he also starred in the film The Zodiac (2005). He had a recurring role in Cold Case (2003) and played Jennifer Lopez's foreign boyfriend in The Wedding Planner (2001).
Pickens literally littered series prior to Grey's, including Curb Your Enthusiasm (2005), Jack and Bobby (2004), The West Wing (2004), The Lyon's Den (2003), Six Feet Under (2002-3), The X-Files (1998-2002), The Practice (1997-2000) and more (Brooklyn South, Roseanne, Beveryly Hills 90210...).
HInton's first credited role was in a movie called Rain (2006). Finding her earlier roles is difficult, but she put some videos of commercials up on YouTube, including this Hanes "wedgie" classic she did with Sarah Chalke in 2008!
When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.
Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."