Though Joel McHale has done plenty of comedy and appeared in several movies and shows, he's best known as the talk show host of the E! channel's The Soup. However, if you want him to make you laugh out loud with scipted comedy, check him out in Community every week as the lead character, Jeff Winger. He's pretty damn fantastic.
Oh and don't confuse him with Ryan Seacrest. Joel McHale? Way cooler.