A classic Grey's Anatomy clip from Season 2, in the episode "Thanks For the Memories."
Derek comforts Meredith as she reacts to a patient's condition and her own mother's fate. The song playing is "Scratch" by Kendall Payne.
Seriously. Meredith and Izzie are spurned by the respective objects of their affections, and turn to George, who just wishes he could go to sleep.
At the beginning of "Name of the Game" (Season 2) Meredith swears off men and booze. While at the bar. Derek and Addison react awkwardly.

Grey's Anatomy Season 2 Quotes

DEREK: "Come on, have a drink."
MEREDITH: "I can't have a drink, I'm celibate."
JOE: "You mean sober? She means sober."
MEREDITH: "No, I mean celibate. I'm practicing celibacy. Drinking does not go well with celibacy because it makes everything and everyone seem kind of porn-y. Then my head gets all cloudy and the next thing you know I'm naked. My point is that I'm celibate, and knitting is good for surgical dexterity, so I'm making a sweater."
DEREK: "You? Celibate? I don't buy it."
MEREDITH: "No more men."
ADDISON: "No more men? Really? You? I'm just asking, because we're friends."
Meredith: Every guy I meet turns out to be married.
DEREK: "Oh... ouch."
MEREDITH: "Or Mark."
ADDISON: [walks away] "Okay, I'm going to sit over there now."
MEREDITH: "Sorry. Or, remember the horrible thing I did? Remember George?"
DEREK: "You're making a sweater."
MEREDITH: "I'm making a sweater."

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."