A classic Grey's Anatomy clip from Season 2, in the episode "Thanks For the Memories."
Derek comforts Meredith as she reacts to a patient's condition and her own mother's fate. The song playing is "Scratch" by Kendall Payne.
Seriously. Meredith and Izzie are spurned by the respective objects of their affections, and turn to George, who just wishes he could go to sleep.
At the beginning of "Name of the Game" (Season 2) Meredith swears off men and booze. While at the bar. Derek and Addison react awkwardly.

Grey's Anatomy Season 2 Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

[shakes her head] "Pissing off the nurses. Stupid move."