This is an awesome confrontation. It's from the episode "Fool Me Once" and shows how angry/wounded Damon has become.
What is the episode "Fool Me Once" all about? The Vampire Diaries producers are here to tell us.
I hope that Elena dies. So says Damon to Stefan in this preview for the episode "Fool Me Once."

The Vampire Diaries Season 1 Episode 14 Quotes

Damon: I mean this sincerely: I hope Elena dies.

All I can remember is hating you. There may been a time when that was different, but your choices have erased that.