You Can't Handle the Truth Promo

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Why are so many people killing themselves? That's the question at the center of this Supernatural episode, as previewed here.
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Supernatural Season 6 Episode 6 Quotes

Dean: Are you kidding me? I have been on red alert about Sam and you come for some stupid horn?
Castiel: You asked me to be here and I came.
Dean: I've been asking you for days you d**k!

Bobby: There's a worse case scenario.
Dean: What? Saying he's my co-pilot? Yeah, I know.
Bobby: No, that'd be the other worst case.
Dean: Then what?
Bobby: Maybe it's just Sam.