Eric Dane to Star in New Movie

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Grey's Anatomy cast member Eric Dane has taken a co-starring role alongside Owen Wilson, Jennifer Aniston and Alan Arkin in Marley & Me.

The feature film - the first for Dane since X-Men United - is an adaptation of John Grogan's bestselling memoir. David Franklin is directing.

Mr. & Mrs. Eric Dane

Mr. and Mrs. Eric Dane (also known as Rebecca Gayheart).

Owen Wilson plays the ambitious reporter who moves with his wife (Aniston) to Miami for a newspaper job. Eric Dane will play the journalist's best friend, who suggests that the reporter adopt a puppy as a substitute for the children his wife wants to have.

Marley, of course, is an adorable Lab puppy but an incorrigible handful.

We're looking forward to Dane's big-screen return in Marley & Me.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith