Grey's Anatomy News & Spoilers: Wednesday Edition

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Season Five of Grey's Anatomy is a little over one week (!) away and the rumors, spoilers and news - not to mention the excitement - surrounding the premiere, are building by the day. What's the latest on our favorite show this morning?

Enter Michael Ausiello of Entertainment Weekly ...

Q: Do you have any inside info on what Season 5 of Grey's Anatomy holds for Izzie and Alex? Their chemistry is great.

A: Let's just say you'll have a really good idea where these two are headed by the end of the two-hour opener on September 25 - which, BTW, I just watched and really enjoyed. Turns out Kevin McKidd is all that and a bag of chips.

Callica

Q: What's going on with Grey's Anatomy's Callica (Callie and Erica)?!

A: There's an awesome, awkward, totally endearing scene between the two of them at the end of the premiere. Sara Ramirez, in particular, is just fantastic. Meanwhile, looking ahead there's buzz that Callica may not be the only members of Seattle Grace's rapidly expanding LGBT community. There's a rumor going around that when the casting call for the new female intern went out last month, interested parties were told they had to be comfortable making out with both men and women. Coincidence then that the actress who got the role hails from The L Word? Only time will tell!

Q: How about some Grey's Anatomy scoop on someone other than Meredith Grey-Derek Shepherd or Cristina Yang-Owen Hunt?

A: The show is casting the role of a female patient who develops a multi-episode crush on one of the docs. My guess: We're looking at a potential love interest for McSteamy.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.