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At long last, the wait is over - and hopefully, good things will follow when Grey's Anatomy makes its 2009 debut this evening with "Wish You Were Here."

In tonight's episode (check out the many videos we've posted for previews), a serial killer on death row, William Dunn (Eric Stoltz) poses an ethical dilemma and makes things difficult for several of our favorite surgeons when he's admitted to Seattle Grace.

Elsewhere, Miranda butts hears with Dr. Arizona Robbins (Jessica Capshaw), Mark wonders how to handle Lexie, and Izzie tells Alex about Denny. Really.

Waiting and Ready

As always, you can talk about "Wish You Were Here" before, during and after the show in our

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

CRISTINA: "There's a club. The Dead Dads Club. And you can't be in it until you're in it. You can try to understand, you can sympathize. But until you feel that loss... My dad died when I was nine. George, I'm really sorry you had to join the club."
GEORGE: "I... I don't know how to exist in a world where my dad doesn't."
CRISTINA: "Yeah, that never really changes."