James Pickens, Jr.: Katherine Heigl, T.R. Knight to Leave Grey's Anatomy Cast This Season

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Here we go again.

The ongoing soap opera concerning Grey's Anatomy stars Katherine Heigl and T.R. Knight and their uncertain futures took another crazy turn today when their co-star, James Pickens, Jr., commented that both of them are indeed leaving the show.

"Yes, she is," Pickens said when asked if the former Emmy winner was checking out of Seattle Grace. "Wherever Katherine goes, I wish her nothing but the best."

And what about T.R. Knight? "He's going too," Pickens, who plays Dr. Richard Webber, Chief of Surgery, said. "He just wanted to pursue other career paths."

BFFs Past and Present

ABC isn't commenting, but according to Entertainment Weekly, sources close to the situation have said regarding Pickens' comments, he may have jumped the gun.

While it's true Heigl and Knight want out, ABC execs have yet to officially issue the actors - who are under contract for six seasons - any Get Out of Jail Free cards.

However, all indications are that it will happen. The only question is when.

"Right now, the whole thing is in the hands of their agents and ABC's lawyers," explains a Grey's Anatomy insider. "Something will probably be worked out soon."

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.