The fifth season premiere of Supernatural, titled "Sympathy for the Devil," picks up where the May finale left off:
Dean and Sam are faced with the Devil (guest star Mark Pellegrino), as he comes back from Hell. The brothers also receive shocking news from Chuck the Prophet: Castiel was blown to bits by the archangels.
The CW series premieres on Thursday night, September 10. Check out a slew of images from the opening episode below: