Nurse Jackie returned for a third season this week with a few relationships changed.

O'Hara is angry at Jackie; Kevin is distrusting of his wife; and Zoey had sex with Lenny.

On next week's new episode, "Enough Rope," we'll see Jackie feel badly when O'Hara considers a new job, Eddie tell his ex-lover that he must be honest with her husband, and Akalitus announce that Michele Obama might stop by for a visit. Check out the following trailer and sneak peeks:

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