When Supernatural returns for a seventh season, Sam and Dean will be "gradually losing touch" with their friends.

So Jared Padalecki tells Entertainment Weekly in a new interview, which previews how "hunters are being killed off" and, of course, how the brothers have lost Castiel, the angel who has been planted on their shoulders in times of need over the years.

How will the boys deal with Castiel's new power? What will happen to Sam now now his wall has crumbled? Check out our Supernatural video section to watch a few clips and get a few ideas; tune in the September 23 premiere for many answers; and click through the following photos from that episode, "Meet the Boss," for an early look at what's to come...