The first Grey's Anatomy sneak peek we posted earlier today featured guest stars Peri Gilpin and Nia Vardalos as sisters awaiting a liver transplant. These next two clips focus on patients as well.

Derek gains an interesting perspective on a potential patient's condition when he attempts to point out that the risks are too great, only to encounter a response that leaves him literally at a loss for words.

Meanwhile, Adele returns to Seattle Grace, looking for Richard ... and she's in bad shape.

It turns out she was walking to the hospital, seven miles away, when her next door neighbor found her. Might this be the last time we see Dr. Webber's wife? The prognosis can't be good.

Watch the two sneak preview clips from "Hope For the Hopeless" below:

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