Who stays? Who goes? Will there be a jaw-dropping tragedy?

Grey's Anatomy spoilers regarding the Season 8 finale and the potential carnage within have been few and far between ... until now. With the fifth-year residents on the verge of major career decisions - potentially in other cities - the show has reached a crossroads with the cast's contract situations as well.

Bottom line: All bets are off.

This Tweet from TV Guide's William Keck is just speculation on his part, but his experience on the set of the season finale does offer some hints at what "Flight" may entail on May 17 ...

And then there's this follow-up, in response to a reader question of who will be back for the show's ninth season in the fall. Apparently at least one familiar face will not be on the 2012-13 roster:

Who do you think is leaving, and how will his/her time on the show conclude? Will there be other departures as well? Sound off with your theories and predictions in the comments below ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.