Sandra Oh Announces Departure from Grey's Anatomy

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Oh? No.

In an interview with The Hollywood Reporter, original Grey's Anatomy cast member Sandra Oh has announced that she will depart the ABC series following its upcoming 10th season.

"Creatively, I really feel like I gave it my all, and I feel ready to let her go," the actress says "It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Cristina] wants to be let go, and I am ready to let her go.

"We have to start the process, story-wise, for the Grey's writers to think of why she's going to go."

Yang Explains

Oh, a five-time Emmy nominee, signed a two-year deal with the series in May 2012 and Shonda Rhimes recently said that she's prepared for other mainstays (including Ellen Pompeo and Patrick Dempsey) to also exit after Season 10, although Oh is the only star so far to make such a decision.

"I've gone through a lot of therapy over this," a tearful Oh said in the interview. "I started thinking about it because I had to prepare myself. I gave myself two years to emotionally let go. At the end of last season, Shonda took me aside and said, 'What are your thoughts?' I said, 'I'm ready.'"

ABC Entertainment President Paul Lee said at this summer's Television Critics Association that he hopes Grey's Anatomy will continue to run for "many years," a sentiment Rhimes has echoed.

So despite the emotional departure of Oh, fans can still look forward to plenty of action at Grey Sloan Memorial well beyond May of next year.

But it simply won't be the same for those who have watched the series since it premiered in 2005.

Grey's Anatomy returns on September 26 with a two-hour premiere. Just how much will you miss Oh as Cristina Yang?!?

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.

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Grey's Anatomy Quotes

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."