No one is safe on Grey's Anatomy, as we realized in the most extreme way on Grey's Anatomy Season 11 Episode 21 when Derek Shepherd was killed off.
When a show lasts as long as Grey's Anatomy has, it makes sense that changes in the cast are going to happen. Still, fans have suffered some pretty terrible losses.
These are rarely simple exits. Grey's Anatomy has given us a long list of tragedies -- with bombs, mass shootings, car wrecks, and plane crashes. Cristina even pointed out the absurdity of it all following the plane crash, calling the hospital "Seattle Grace Mercy Death."
Several characters have been killed off, causing us to cry our ugliest ugly cries and throw things at are television sets. Who can forget the death of George O'Malley on Grey's Anatomy Season 5 Episode 24?
Thankfully, other characters have been offered happy endings -- or at least, send offs that spared their lives.
Which one of these characters do you miss the most and why? Be sure to share your thoughts in the comments below!
Need to catch up on past episodes? Remember that you can always watch Grey's Anatomy online right here via TV Fanatic!