Janice Soprano is Tony's tragic excuse for an older sister on The Sopranos.  She doesn't seem to have much luck with men as they all some to end up dead.

Janice Soprano Quotes

Tony: I'm sellin' Ma's house. You understand, Janice? Now put that fucking sign back in the fucking ground and that's it. End of discussion. Period.
Janice: You're so left brained. Whether the sign is there or not, the house is still for sale. The agent still has the listing.

Some family reunion--the woman who bore them all is barred from the premises.

Janice

The Sopranos Quotes

Junior: A Chinaman goes to see the eye doctor. After the exam the doctor said, "I know why you're having trouble." The Chinaman says, "why?" Doctor said, "you have a cataract." Chinaman says, "no, I have a Rincoln Continental." (short pause) You don't get it?
Bobby: I get it. He drives a Lincoln Continental. What?

Dr. Melfi: What's the one thing every woman - your mother, your wife, your daughter - have in common?
Tony: They all break my balls. No, I know what you mean. They're all Italian. So what?
Dr. Melfi: So maybe by coming clean with me you're dialoguing with them.